Csaba Leranth MD, Ph.D.

Professor of Obstetrics, Gynecology, and Reproductive Sciences and of Neurobiology

Research Interests

Positive gonadal hormonal negative bisphenol A

Current Projects

Bisphenol A effect on the non-human primate brain.

Gene therapy of primate model of Parkinsons disease.

Morphological changes in the primate brain in PCP model of schizophrenia.

Research Summary

Positive gonadal hormonal and negative bisphenol A effects on brain areas involved mnemonic functions (hippocampus and prefrontal cortex) of females and males

Selected Publications

  • Hajszan T and Leranth C (2010) Bisphenol A interferes with synaptic remodeling. Front Neuroendocrinology Epub Ahead of print. PMID: 20609373
  • Hajszan T, Szigeti-Buck K, Sallam NL, Bober J, Parducz A, MacLusky NJ, Leranth C, Duman RS (2009) Remodeling of hippocampal spine synapses in rat learned helplessness model of depression. Biological Psychiatry (65:392-400)
  • Leranth C, Hajszan T, Szigeti-Buck K, Bober J, Maclusky NJ. (2008) Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proc Natl Acad Sci U S A 105:14187-14191
  • Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T (2008) Bisphenol A prevents the synaptogenic response to testosterone in the brain of adult male rats. Endocrinology 149: 988-994
  • Hajszan T, Milner TA, and `Leranth C (2007) Sex steroids and the dentate gyrus. In: The Dentate Gyrus. Ed. Scharfman HE. Elsevier, Amsterdam, Progr in Brain Res. 163:397-413
  • Leranth C and Hajszan T (2007) Extrinsic afferent systems to the dentate gyrus. In: The Dentate Gyrus. Ed. Scharfman HE. Elsevier, Amsterdam, Progr in Brain Res. 163:63-84
  • Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH (2007) Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 61:862-865
  • Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C (2007) Effects of androgen and estradiol on spine synapse formation in the prefrontal cortex of normal and testicular feminization mutant male rats. Endocrinology 148: 1963-1967
  • MacLusky NJ, Hajszan T, Johansen J-A, Jordan CL, Leranth C (2006) Androgen effects on hippocampal CA1 spine synapse numbers are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 148: 1963-1967
  • MacLusky NJ, Hajszan T, Leranth, C (2005) The environmental estrogen bisphenol A inhibits estrogen-induced hippocampal synaptogenesis Environmental Health Perspectives 113:675-679

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